Structural Characterization and Physicochemical Stability Profile of a Double Mutant Heat Labile Toxin Protein Based Adjuvant

A novel protein adjuvant double-mutant Escherichia coli heat-labile toxin, LT (R192G/L211A) or dmLT, is in preclinical and early clinical development with various vaccine candidates. Structural characterization and formulation development of dmLT will play a key role in its successful process develo...

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Vydáno v:J Pharm Sci
Hlavní autoři: Toprani, Vishal M., Hickey, John M., Sahni, Neha, Toth, Ronald T., Robertson, George A., Middaugh, C. Russell, Joshi, Sangeeta B., Volkin, David B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690273/
https://ncbi.nlm.nih.gov/pubmed/28780391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2017.07.019
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