Comprehensive molecular characterization of muscle invasive bladder cancer

We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a...

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Publicado en:Cell
Main Authors: Robertson, A. Gordon, Kim, Jaegil, Al-Ahmadie, Hikmat, Bellmunt, Joaquim, Guo, Guangwu, Cherniack, Andrew D., Hinoue, Toshinori, Laird, Peter W., Hoadley, Katherine A., Akbani, Rehan, Castro, Mauro A.A., Gibb, Ewan A., Kanchi, Rupa S., Gordenin, Dmitry A., Shukla, Sachet A., Sanchez-Vega, Francisco, Hansel, Donna E., Czerniak, Bogdan A., Reuter, Victor E., Su, Xiaoping, de Sa Carvalho, Benilton, Chagas, Vinicius S., Mungall, Karen L., Sadeghi, Sara, Pedamallu, Chandra Sekhar, Lu, Yiling, Klimczak, Leszek J., Zhang, Jiexin, Choo, Caleb, Ojesina, Akinyemi I., Bullman, Susan, Leraas, Kristen M., Lichtenberg, Tara M., Wu, Catherine J., Schultz, Nicholaus, Getz, Gad, Meyerson, Matthew, Mills, Gordon B., McConkey, David J., Weinstein, John N., Kwiatkowski, David J., Lerner, Seth P.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687509/
https://ncbi.nlm.nih.gov/pubmed/28988769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.007
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