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Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8
[Image: see text] A series of N1-modified imidazoquinolines were synthesized and screened for Toll-like receptors (TLR) 7 and 8 activities to identify recognition elements that confer high affinity binding and selectivity. These receptors are key targets in the development of immunomodulatory agents...
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| Опубликовано в: : | ACS Med Chem Lett |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical
Society
2017
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5683703/ https://ncbi.nlm.nih.gov/pubmed/29152046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00256 |
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