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Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles
Several synthetic heterocyclic small molecules like imiquimod, resiquimod, CL097, CL075, bromopirone, tilorone, loxoribine and isatoribine demonstrated TLR7/8 agonistic activity and relatively modest structural changes in such molecules result in major variation in the TLR7 and/or TLR8 activity. A s...
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| Publicado no: | RSC Med Chem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
RSC
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8292987/ https://ncbi.nlm.nih.gov/pubmed/34355178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1md00031d |
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