Suppressing allostery in epitope mapping experiments using millisecond hydrogen / deuterium exchange mass spectrometry

Localization of the interface between the candidate antibody and its antigen target, commonly known as epitope mapping, is a critical component of the development of therapeutic monoclonal antibodies. With the recent availability of commercial automated systems, hydrogen / deuterium eXchange (HDX) i...

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Veröffentlicht in:MAbs
Hauptverfasser: Deng, Bin, Zhu, Shaolong, Macklin, Andrew M., Xu, Jianrong, Lento, Cristina, Sljoka, Adnan, Wilson, Derek J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680795/
https://ncbi.nlm.nih.gov/pubmed/28933661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1379641
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