The mystery of oncogenic KRAS: Lessons from studying its wild-type counter part

Using conditional knock-in mouse models, we and others have shown that despite the very high sequence identity between Nras and Kras proteins, oncogenic Kras displays a much stronger leukemogenic activity than oncogenic Nras in vivo. In this manuscript, we will summarize our recent work of character...

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Bibliografiska uppgifter
I publikationen:Small GTPases
Huvudupphovsmän: Chang, Yuan-I, Damnernsawad, Alisa, Kong, Guangyao, You, Xiaona, Wang, Demin, Zhang, Jing
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2016
Ämnen:
Commentary
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680677/
https://ncbi.nlm.nih.gov/pubmed/27449543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2016.1215656
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