Activation of autophagy ameliorates cardiomyopathy in Mybpc3-targeted knock-in mice

BACKGROUND: Alterations in autophagy have been reported in hypertrophic cardiomyopathy (HCM) caused by Danon disease, Vici syndrome or LEOPARD syndrome, but not in HCM caused by mutations in genes encoding sarcomeric proteins, which account for most of HCM cases. MYBPC3, encoding cardiac myosin-bind...

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Udgivet i:Circ Heart Fail
Main Authors: Singh, Sonia R., Zech, Antonia T.L., Geertz, Birgit, Reischmann-Düsener, Silke, Osinska, Hanna, Prondzynski, Maksymilian, Krämer, Elisabeth, Meng, Qinghang, Redwood, Charles, van der Velden, Jolanda, Robbins, Jeffrey, Schlossarek, Saskia, Carrier, Lucie
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679453/
https://ncbi.nlm.nih.gov/pubmed/29021349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004140
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