Diltiazem prevents stress‐induced contractile deficits in cardiomyocytes, but does not reverse the cardiomyopathy phenotype in Mybpc3‐knock‐in mice

KEY POINTS: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac illness and can lead to diastolic dysfunction, sudden cardiac death and heart failure. Treatment of HCM patients is empirical and current pharmacological treatments are unable to stop disease progression or reverse hy...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Flenner, Frederik, Geertz, Birgit, Reischmann‐Düsener, Silke, Weinberger, Florian, Eschenhagen, Thomas, Carrier, Lucie, Friedrich, Felix W.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Regulation of Contractile Function in Health and Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471503/
https://ncbi.nlm.nih.gov/pubmed/28090637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273769
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