Diltiazem prevents stress‐induced contractile deficits in cardiomyocytes, but does not reverse the cardiomyopathy phenotype in Mybpc3‐knock‐in mice

KEY POINTS: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac illness and can lead to diastolic dysfunction, sudden cardiac death and heart failure. Treatment of HCM patients is empirical and current pharmacological treatments are unable to stop disease progression or reverse hy...

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Detalles Bibliográficos
Publicado en:J Physiol
Autores principales: Flenner, Frederik, Geertz, Birgit, Reischmann‐Düsener, Silke, Weinberger, Florian, Eschenhagen, Thomas, Carrier, Lucie, Friedrich, Felix W.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Regulation of Contractile Function in Health and Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471503/
https://ncbi.nlm.nih.gov/pubmed/28090637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273769
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