Activation of autophagy ameliorates cardiomyopathy in Mybpc3-targeted knock-in mice

BACKGROUND: Alterations in autophagy have been reported in hypertrophic cardiomyopathy (HCM) caused by Danon disease, Vici syndrome or LEOPARD syndrome, but not in HCM caused by mutations in genes encoding sarcomeric proteins, which account for most of HCM cases. MYBPC3, encoding cardiac myosin-bind...

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Publicado no:Circ Heart Fail
Main Authors: Singh, Sonia R., Zech, Antonia T.L., Geertz, Birgit, Reischmann-Düsener, Silke, Osinska, Hanna, Prondzynski, Maksymilian, Krämer, Elisabeth, Meng, Qinghang, Redwood, Charles, van der Velden, Jolanda, Robbins, Jeffrey, Schlossarek, Saskia, Carrier, Lucie
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679453/
https://ncbi.nlm.nih.gov/pubmed/29021349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004140
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