A Direct In Vivo Comparison of The Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH(2) versus The Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH(2): A Bivalent Advantage

Bivalent ligands targeting putative melanocortin receptor dimers have been developed and characterized in vitro, however studies of their functional in vivo effects have been limited. The current report compares the effects of homobivalent ligand CJL-1-87, Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp...

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Publicado en:ACS Chem Neurosci
Autores principales: Lensing, Cody J., Adank, Danielle N., Wilber, Stacey L., Freeman, Katie T., Schnell, Sathya M., Speth, Robert C., Zarth, Adam T., Haskell-Luevano, Carrie
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679024/
https://ncbi.nlm.nih.gov/pubmed/28128928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00399
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