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Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
[Image: see text] Huntington’s disease is caused by expansion of a polyglutamine (polyQ) domain within exon 1 of the huntingtin gene (Httex1). The prevailing hypothesis is that the monomeric Httex1 protein undergoes sharp conformational changes as the polyQ length exceeds a threshold of 36–37 residu...
Guardat en:
| Publicat a: | J Am Chem Soc |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2017
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5677759/ https://ncbi.nlm.nih.gov/pubmed/28937758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b06659 |
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