Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths

[Image: see text] Huntington’s disease is caused by expansion of a polyglutamine (polyQ) domain within exon 1 of the huntingtin gene (Httex1). The prevailing hypothesis is that the monomeric Httex1 protein undergoes sharp conformational changes as the polyQ length exceeds a threshold of 36–37 residu...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Warner, John B., Ruff, Kiersten M., Tan, Piau Siong, Lemke, Edward A., Pappu, Rohit V., Lashuel, Hilal A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5677759/
https://ncbi.nlm.nih.gov/pubmed/28937758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b06659
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