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Allosteric Regulation of Epigenetic Modifying Enzymes
Epigenetic enzymes including histone modifying enzymes are key regulators of gene expression in normal and disease processes. Many drug development strategies to target histone modifying enzymes have focused on ligands that bind to enzyme active sites, but allosteric pockets offer potentially attrac...
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| Veröffentlicht in: | Curr Opin Chem Biol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5675028/ https://ncbi.nlm.nih.gov/pubmed/28689145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2017.05.015 |
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