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Statins Do Not Directly Inhibit the Activity of Major Epigenetic Modifying Enzymes

The potential anticancer effects of statins—a widely used class of cholesterol lowering drugs—has generated significant interest, as has the use of epigenetic modifying drugs such as HDAC and DNMT inhibitors. We set out to investigate the effect of statin drugs on epigenetic modifications in multipl...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Bridgeman, Stephanie, Northrop, Wendy, Ellison, Gaewyn, Sabapathy, Thiru, Melton, Phillip E., Newsholme, Philip, Mamotte, Cyril D. S.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521159/
https://ncbi.nlm.nih.gov/pubmed/30974899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11040516
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