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Allosteric Regulation of Epigenetic Modifying Enzymes

Epigenetic enzymes including histone modifying enzymes are key regulators of gene expression in normal and disease processes. Many drug development strategies to target histone modifying enzymes have focused on ligands that bind to enzyme active sites, but allosteric pockets offer potentially attrac...

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Detalhes bibliográficos
Publicado no:Curr Opin Chem Biol
Main Authors: Zucconi, Beth E., Cole, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675028/
https://ncbi.nlm.nih.gov/pubmed/28689145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2017.05.015
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