Tandem repeat variation near the HIC1 promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer

BACKGROUND: The hypermethylated in cancer 1/Sirtuin 1 (HIC1/SIRT1) axis plays an important role in regulating the nucleotide excision repair pathway, which is the main oxaliplatin-induced damage repair system. Based on prior evidence that the variable number of tandem repeat (VNTR) sequence located...

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Gepubliceerd in:Cancer
Hoofdauteurs: Okazaki, Satoshi, Schirripa, Marta, Loupakis, Fotios, Cao, Shu, Zhang, Wu, Yang, Dongyun, Ning, Yan, Berger, Martin D., Miyamoto, Yuji, Suenaga, Mitsukuni, Iqubal, Syma, Barzi, Afsaneh, Cremolini, Chiara, Falcone, Alfredo, Battaglin, Francesca, Salvatore, Lisa, Borelli, Beatrice, Helentjaris, Timothy G., Lenz, Heinz-Josef
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673544/
https://ncbi.nlm.nih.gov/pubmed/28708932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30880
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