The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling

Several somatic ribosome defects have recently been discovered in cancer, yet their oncogenic mechanisms remain poorly understood. Here we investigated the pathogenic role of the recurrent R98S mutation in ribosomal protein L10 (RPL10-R98S) found in T-ALL. The JAK-STAT signaling pathway is a critica...

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Publicado en:Leukemia
Autores principales: Girardi, Tiziana, Vereecke, Stijn, Sulima, Sergey O., Khan, Yousuf, Fancello, Laura, Briggs, Joseph W., Schwab, Claire, de Beeck, Joyce Op, Verbeeck, Jelle, Royaert, Jonathan, Geerdens, Ellen, Vicente, Carmen, Bornschein, Simon, Harrison, Christine J., Meijerink, Jules P., Cools, Jan, Dinman, Jonathan D., Kampen, Kim R., De Keersmaecker, Kim
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669462/
https://ncbi.nlm.nih.gov/pubmed/28744013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.225
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