The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling

Several somatic ribosome defects have recently been discovered in cancer, yet their oncogenic mechanisms remain poorly understood. Here we investigated the pathogenic role of the recurrent R98S mutation in ribosomal protein L10 (RPL10-R98S) found in T-ALL. The JAK-STAT signaling pathway is a critica...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Girardi, Tiziana, Vereecke, Stijn, Sulima, Sergey O., Khan, Yousuf, Fancello, Laura, Briggs, Joseph W., Schwab, Claire, de Beeck, Joyce Op, Verbeeck, Jelle, Royaert, Jonathan, Geerdens, Ellen, Vicente, Carmen, Bornschein, Simon, Harrison, Christine J., Meijerink, Jules P., Cools, Jan, Dinman, Jonathan D., Kampen, Kim R., De Keersmaecker, Kim
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669462/
https://ncbi.nlm.nih.gov/pubmed/28744013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.225
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