The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling

Several somatic ribosome defects have recently been discovered in cancer, yet their oncogenic mechanisms remain poorly understood. Here we investigated the pathogenic role of the recurrent R98S mutation in ribosomal protein L10 (RPL10-R98S) found in T-ALL. The JAK-STAT signaling pathway is a critica...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Leukemia
Auteurs principaux: Girardi, Tiziana, Vereecke, Stijn, Sulima, Sergey O., Khan, Yousuf, Fancello, Laura, Briggs, Joseph W., Schwab, Claire, de Beeck, Joyce Op, Verbeeck, Jelle, Royaert, Jonathan, Geerdens, Ellen, Vicente, Carmen, Bornschein, Simon, Harrison, Christine J., Meijerink, Jules P., Cools, Jan, Dinman, Jonathan D., Kampen, Kim R., De Keersmaecker, Kim
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669462/
https://ncbi.nlm.nih.gov/pubmed/28744013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.225
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires