Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol

Most studies of responses to transcriptional stimuli measure changes in cellular mRNA concentrations. By sequencing nascent RNA instead, it is possible to detect changes in transcription in minutes rather than hours and thereby distinguish primary from secondary responses to regulatory signals. Here...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Dukler, Noah, Booth, Gregory T., Huang, Yi-Fei, Tippens, Nathaniel, Waters, Colin T., Danko, Charles G., Lis, John T., Siepel, Adam
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668940/
https://ncbi.nlm.nih.gov/pubmed/29025894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.222935.117
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