Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol

Most studies of responses to transcriptional stimuli measure changes in cellular mRNA concentrations. By sequencing nascent RNA instead, it is possible to detect changes in transcription in minutes rather than hours and thereby distinguish primary from secondary responses to regulatory signals. Here...

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Dades bibliogràfiques
Publicat a:Genome Res
Autors principals: Dukler, Noah, Booth, Gregory T., Huang, Yi-Fei, Tippens, Nathaniel, Waters, Colin T., Danko, Charles G., Lis, John T., Siepel, Adam
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668940/
https://ncbi.nlm.nih.gov/pubmed/29025894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.222935.117
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