Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol

Most studies of responses to transcriptional stimuli measure changes in cellular mRNA concentrations. By sequencing nascent RNA instead, it is possible to detect changes in transcription in minutes rather than hours and thereby distinguish primary from secondary responses to regulatory signals. Here...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genome Res
Prif Awduron: Dukler, Noah, Booth, Gregory T., Huang, Yi-Fei, Tippens, Nathaniel, Waters, Colin T., Danko, Charles G., Lis, John T., Siepel, Adam
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2017
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668940/
https://ncbi.nlm.nih.gov/pubmed/29025894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.222935.117
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