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Phylogenetic Modeling of Regulatory Element Turnover Based on Epigenomic Data

Evolutionary changes in gene expression are often driven by gains and losses of cis-regulatory elements (CREs). The dynamics of CRE evolution can be examined using multispecies epigenomic data, but so far such analyses have generally been descriptive and model-free. Here, we introduce a probabilisti...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Dukler, Noah, Huang, Yi-Fei, Siepel, Adam
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7306682/
https://ncbi.nlm.nih.gov/pubmed/32176292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msaa073
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