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Estimation of allele-specific fitness effects across human protein-coding sequences and implications for disease
A central challenge in human genomics is to understand the cellular, evolutionary, and clinical significance of genetic variants. Here, we introduce a unified population-genetic and machine-learning model, called Linear Allele-Specific Selection InferencE (LASSIE), for estimating the fitness effects...
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| Publicado no: | Genome Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6673719/ https://ncbi.nlm.nih.gov/pubmed/31249063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.245522.118 |
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