Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol

Most studies of responses to transcriptional stimuli measure changes in cellular mRNA concentrations. By sequencing nascent RNA instead, it is possible to detect changes in transcription in minutes rather than hours and thereby distinguish primary from secondary responses to regulatory signals. Here...

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Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Dukler, Noah, Booth, Gregory T., Huang, Yi-Fei, Tippens, Nathaniel, Waters, Colin T., Danko, Charles G., Lis, John T., Siepel, Adam
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668940/
https://ncbi.nlm.nih.gov/pubmed/29025894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.222935.117
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