Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model

BACKGROUND: Dysregulation of the Src pathway has been shown to be important at various stages of cancer. Dasatinib is a potent Src/Abl inhibitor and has demonstrated to have anti-proliferative and anti-invasive activity in many preclinical models. The objective of this study was to determine the ant...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Scott, Aaron J., Song, Eun-Kee, Bagby, Stacey, Purkey, Alicia, McCarter, Martin, Gajdos, Csaba, Quackenbush, Kevin S., Cross, Benjamin, Pitts, Todd M., Tan, Aik Choon, Eckhardt, S. Gail, Fenton, Hubert, Arcaroli, John, Messersmith, Wells A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665512/
https://ncbi.nlm.nih.gov/pubmed/29091939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187173
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