Potent antitumor activity of Cabozantinib, a c-MET and VEGFR2 Inhibitor, in a Colorectal Cancer Patient-derived Tumor Explant Model

Anti-angiogenic therapy is commonly used for the treatment of CRC. Although patients derive some clinical benefit, treatment resistance inevitably occurs. The MET signaling pathway has been proposed to be a major contributor of resistance to anti-angiogenic therapy. MET is upregulated in response to...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Song, Eun-Kee, Tai, WM, Messersmith, Wells A., Bagby, Stacey, Purkey, Alicia, Quackenbush, Kevin S., Pitts, Todd M., Wang, Guoliang, Blatchford, Patrick, Yahn, Rachel, Kaplan, Jeffrey, Tan, Aik Choon, Atreya, Chloe E., Eckhardt, Gail, Kelley, Robin K., Venook, Alan, Kwak, Eunice L, Ryan, David, Arcaroli, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323738/
https://ncbi.nlm.nih.gov/pubmed/25242168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29225
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