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A composite docking approach for the identification and characterization of ectosteric inhibitors of cathepsin K

Cathepsin K (CatK) is a cysteine protease that plays an important role in mammalian intra- and extracellular protein turnover and is known for its unique and potent collagenase activity. Through studies on the mechanism of its collagenase activity, selective ectosteric sites were identified that are...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Law, Simon, Panwar, Preety, Li, Jody, Aguda, Adeleke H., Jamroz, Andrew, Guido, Rafael V. C., Brömme, Dieter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663397/
https://ncbi.nlm.nih.gov/pubmed/29088253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186869
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