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A composite docking approach for the identification and characterization of ectosteric inhibitors of cathepsin K
Cathepsin K (CatK) is a cysteine protease that plays an important role in mammalian intra- and extracellular protein turnover and is known for its unique and potent collagenase activity. Through studies on the mechanism of its collagenase activity, selective ectosteric sites were identified that are...
Shranjeno v:
| izdano v: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5663397/ https://ncbi.nlm.nih.gov/pubmed/29088253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186869 |
| Oznake: |
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