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A composite docking approach for the identification and characterization of ectosteric inhibitors of cathepsin K
Cathepsin K (CatK) is a cysteine protease that plays an important role in mammalian intra- and extracellular protein turnover and is known for its unique and potent collagenase activity. Through studies on the mechanism of its collagenase activity, selective ectosteric sites were identified that are...
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| Publicat a: | PLoS One |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5663397/ https://ncbi.nlm.nih.gov/pubmed/29088253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186869 |
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