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Optimized sequence library design for efficient in vitro interaction mapping

Sequence libraries that cover all k-mers enable universal, unbiased measurements of binding to both oligonucleotides and peptides. While the number of k-mers grows exponentially in k, space on all experimental platforms is limited. Here, we shrink k-mer library sizes by using joker characters, which...

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Bibliografski detalji
Izdano u:Cell Syst
Glavni autori: Orenstein, Yaron, Puccinelli, Robert, Kim, Ryan, Fordyce, Polly, Berger, Bonnie
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661997/
https://ncbi.nlm.nih.gov/pubmed/28957657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2017.07.006
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