Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma

Glioblastoma (GBM), the most aggressive brain cancer, is highly dependent on the mevalonate (MVA) pathway for the synthesis of lipid moieties critical for cell proliferation but the function and regulation of key intermediate enzymes like farnesyl-diphosphate synthase (FDPS), up to now, remained unk...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Abate, Mario, Laezza, Chiara, Pisanti, Simona, Torelli, Giovanni, Seneca, Vincenzo, Catapano, Giuseppe, Montella, Francesco, Ranieri, Roberta, Notarnicola, Maria, Gazzerro, Patrizia, Bifulco, Maurizio, Ciaglia, Elena
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658376/
https://ncbi.nlm.nih.gov/pubmed/29075041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14495-6
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