N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux

Targeting the autophagic process is considered a promising therapeutic strategy in cancer since a great number of tumors, including melanoma, show high basal levels of protective autophagy that contributes to tumor progression and chemoresistance. Here, exploiting both in vitro and in vivo approache...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Ranieri, Roberta, Ciaglia, Elena, Amodio, Giuseppina, Picardi, Paola, Proto, Maria Chiara, Gazzerro, Patrizia, Laezza, Chiara, Remondelli, Paolo, Bifulco, Maurizio, Pisanti, Simona
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2018
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762849/
https://ncbi.nlm.nih.gov/pubmed/29027991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.165
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