N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux

Targeting the autophagic process is considered a promising therapeutic strategy in cancer since a great number of tumors, including melanoma, show high basal levels of protective autophagy that contributes to tumor progression and chemoresistance. Here, exploiting both in vitro and in vivo approache...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Differ
Prif Awduron: Ranieri, Roberta, Ciaglia, Elena, Amodio, Giuseppina, Picardi, Paola, Proto, Maria Chiara, Gazzerro, Patrizia, Laezza, Chiara, Remondelli, Paolo, Bifulco, Maurizio, Pisanti, Simona
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2018
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762849/
https://ncbi.nlm.nih.gov/pubmed/29027991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.165
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