Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients' cells

Herein we show that a majority of human brain tumor samples and cell lines over-expressed cannabinoid receptor CB1 as compared to normal human astrocytes (NHA), while uniformly expressed low levels of CB2. This finding prompted us to investigate the therapeutic exploitation of CB1 inactivation by SR...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Ciaglia, Elena, Torelli, Giovanni, Pisanti, Simona, Picardi, Paola, D'Alessandro, Alba, Laezza, Chiara, Malfitano, Anna Maria, Fiore, Donatella, Zottola, Antonio Christian Pagano, Proto, Maria Chiara, Catapano, Giuseppe, Gazzerro, Patrizia, Bifulco, Maurizio
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558164/
https://ncbi.nlm.nih.gov/pubmed/26008966
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