Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma

Glioblastoma (GBM), the most aggressive brain cancer, is highly dependent on the mevalonate (MVA) pathway for the synthesis of lipid moieties critical for cell proliferation but the function and regulation of key intermediate enzymes like farnesyl-diphosphate synthase (FDPS), up to now, remained unk...

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Publicado en:Sci Rep
Autores principales: Abate, Mario, Laezza, Chiara, Pisanti, Simona, Torelli, Giovanni, Seneca, Vincenzo, Catapano, Giuseppe, Montella, Francesco, Ranieri, Roberta, Notarnicola, Maria, Gazzerro, Patrizia, Bifulco, Maurizio, Ciaglia, Elena
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658376/
https://ncbi.nlm.nih.gov/pubmed/29075041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14495-6
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