Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma

Glioblastoma (GBM), the most aggressive brain cancer, is highly dependent on the mevalonate (MVA) pathway for the synthesis of lipid moieties critical for cell proliferation but the function and regulation of key intermediate enzymes like farnesyl-diphosphate synthase (FDPS), up to now, remained unk...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Abate, Mario, Laezza, Chiara, Pisanti, Simona, Torelli, Giovanni, Seneca, Vincenzo, Catapano, Giuseppe, Montella, Francesco, Ranieri, Roberta, Notarnicola, Maria, Gazzerro, Patrizia, Bifulco, Maurizio, Ciaglia, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658376/
https://ncbi.nlm.nih.gov/pubmed/29075041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14495-6
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