Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma

Glioblastoma (GBM), the most aggressive brain cancer, is highly dependent on the mevalonate (MVA) pathway for the synthesis of lipid moieties critical for cell proliferation but the function and regulation of key intermediate enzymes like farnesyl-diphosphate synthase (FDPS), up to now, remained unk...

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Udgivet i:Sci Rep
Main Authors: Abate, Mario, Laezza, Chiara, Pisanti, Simona, Torelli, Giovanni, Seneca, Vincenzo, Catapano, Giuseppe, Montella, Francesco, Ranieri, Roberta, Notarnicola, Maria, Gazzerro, Patrizia, Bifulco, Maurizio, Ciaglia, Elena
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658376/
https://ncbi.nlm.nih.gov/pubmed/29075041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14495-6
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