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A machine learning approach for predicting CRISPR-Cas9 cleavage efficiencies and patterns underlying its mechanism of action

The adaptation of the CRISPR-Cas9 system as a genome editing technique has generated much excitement in recent years owing to its ability to manipulate targeted genes and genomic regions that are complementary to a programmed single guide RNA (sgRNA). However, the efficacy of a specific sgRNA is not...

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發表在:PLoS Comput Biol
Main Authors: Abadi, Shiran, Yan, Winston X., Amar, David, Mayrose, Itay
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658169/
https://ncbi.nlm.nih.gov/pubmed/29036168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005807
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