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Computational Analysis Concerning the Impact of DNA Accessibility on CRISPR-Cas9 Cleavage Efficiency
Defining the variables that impact the specificity of CRISPR/Cas9 has been a major research focus. Whereas sequence complementarity between guide RNA and target DNA substantially dictates cleavage efficiency, DNA accessibility of the targeted loci has also been hypothesized to be an important factor...
Shranjeno v:
| izdano v: | Mol Ther |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Gene & Cell Therapy
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6953893/ https://ncbi.nlm.nih.gov/pubmed/31672284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.10.008 |
| Oznake: |
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