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CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
Chronic hepatitis B virus (HBV) infection is prevalent, deadly, and seldom cured due to the persistence of viral episomal DNA (cccDNA) in infected cells. Newly developed genome engineering tools may offer the ability to directly cleave viral DNA, thereby promoting viral clearance. Here, we show that...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4649911/ https://ncbi.nlm.nih.gov/pubmed/26035283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10833 |
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