CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

Chronic hepatitis B virus (HBV) infection is prevalent, deadly, and seldom cured due to the persistence of viral episomal DNA (cccDNA) in infected cells. Newly developed genome engineering tools may offer the ability to directly cleave viral DNA, thereby promoting viral clearance. Here, we show that...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Ramanan, Vyas, Shlomai, Amir, Cox, David B.T., Schwartz, Robert E., Michailidis, Eleftherios, Bhatta, Ankit, Scott, David A., Zhang, Feng, Rice, Charles M., Bhatia, Sangeeta N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649911/
https://ncbi.nlm.nih.gov/pubmed/26035283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10833
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