Increased Plasma BACE1 May Predict Conversion to Alzheimer’s Disease Dementia in Individuals With Mild Cognitive Impairment

BACKGROUND: Increased β-secretase (BACE1) activity has consistently been detected in the brain tissue and cerebrospinal fluid (CSF) of subjects with mild cognitive impairment (MCI) and probable Alzheimer’s disease (AD) compared to controls. The collection of CSF by lumbar puncture is invasive. We so...

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Detalhes bibliográficos
Publicado no:Biol Psychiatry
Main Authors: Shen, Yong, Wang, Haibo, Sun, Qiying, Yao, Hailan, Keegan, Andrew P, Mullan, Mike, Wilson, Jeffrey, Lista, Simone, Leyhe, Thomas, Laske, Christoph, Rujescu, Dan, Levey, Allan, Wallin, Anders, Blennow, Kaj, Li, Rena, Hampel, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656540/
https://ncbi.nlm.nih.gov/pubmed/28359566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.02.007
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