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High Activities of BACE1 in Brains with Mild Cognitive Impairment

We recently discovered elevated β-secretase 1 (BACE1) activity in brains with sporadic Alzheimer disease (AD). Moreover, we also found high levels of BACE1 enzymatic activity in the cerebrospinal fluid from patients with both mild cognitive impairment (MCI) and AD. These results suggest that elevati...

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Détails bibliographiques
Auteurs principaux: Cheng, Xin, He, Ping, Lee, Taehee, Yao, Hailan, Li, Rena, Shen, Yong
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873486/
https://ncbi.nlm.nih.gov/pubmed/24332014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.10.002
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