Increased Plasma BACE1 May Predict Conversion to Alzheimer’s Disease Dementia in Individuals With Mild Cognitive Impairment

BACKGROUND: Increased β-secretase (BACE1) activity has consistently been detected in the brain tissue and cerebrospinal fluid (CSF) of subjects with mild cognitive impairment (MCI) and probable Alzheimer’s disease (AD) compared to controls. The collection of CSF by lumbar puncture is invasive. We so...

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Dades bibliogràfiques
Publicat a:Biol Psychiatry
Autors principals: Shen, Yong, Wang, Haibo, Sun, Qiying, Yao, Hailan, Keegan, Andrew P, Mullan, Mike, Wilson, Jeffrey, Lista, Simone, Leyhe, Thomas, Laske, Christoph, Rujescu, Dan, Levey, Allan, Wallin, Anders, Blennow, Kaj, Li, Rena, Hampel, Harald
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656540/
https://ncbi.nlm.nih.gov/pubmed/28359566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.02.007
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