Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

BACKGROUND: Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DDIs). As anti-malarials are generally positively charged at p...

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Dades bibliogràfiques
Publicat a:Malar J
Autors principals: van der Velden, Maarten, Bilos, Albert, van den Heuvel, Jeroen J. M. W., Rijpma, Sanna R., Hurkmans, Evelien G. E., Sauerwein, Robert W., Russel, Frans G. M., Koenderink, Jan B.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654082/
https://ncbi.nlm.nih.gov/pubmed/29061131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-017-2062-y
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