Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

BACKGROUND: Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DDIs). As anti-malarials are generally positively charged at p...

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Bibliografiske detaljer
Udgivet i:Malar J
Main Authors: van der Velden, Maarten, Bilos, Albert, van den Heuvel, Jeroen J. M. W., Rijpma, Sanna R., Hurkmans, Evelien G. E., Sauerwein, Robert W., Russel, Frans G. M., Koenderink, Jan B.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654082/
https://ncbi.nlm.nih.gov/pubmed/29061131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-017-2062-y
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