Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

BACKGROUND: Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DDIs). As anti-malarials are generally positively charged at p...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: van der Velden, Maarten, Bilos, Albert, van den Heuvel, Jeroen J. M. W., Rijpma, Sanna R., Hurkmans, Evelien G. E., Sauerwein, Robert W., Russel, Frans G. M., Koenderink, Jan B.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654082/
https://ncbi.nlm.nih.gov/pubmed/29061131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-017-2062-y
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