Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates

Paracetamol (acetaminophen, APAP) overdose is a leading cause of acute drug-induced liver failure. APAP hepatotoxicity is mediated by the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI). NAPQI is inactivated by conjugation with glutathione (GSH) to APAP-GSH, which is further converted into...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Koenderink, Jan B., van den Heuvel, Jeroen J. M. W., Bilos, Ab, Vredenburg, Galvin, Vermeulen, Nico P. E., Russel, Frans G. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Toxicokinetics and Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415487/
https://ncbi.nlm.nih.gov/pubmed/32472168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02793-4
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