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Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates

Paracetamol (acetaminophen, APAP) overdose is a leading cause of acute drug-induced liver failure. APAP hepatotoxicity is mediated by the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI). NAPQI is inactivated by conjugation with glutathione (GSH) to APAP-GSH, which is further converted into...

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Bibliografske podrobnosti
izdano v:	Arch Toxicol
Main Authors:	Koenderink, Jan B., van den Heuvel, Jeroen J. M. W., Bilos, Ab, Vredenburg, Galvin, Vermeulen, Nico P. E., Russel, Frans G. M.
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer Berlin Heidelberg 2020
Teme:	Toxicokinetics and Metabolism
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7415487/ https://ncbi.nlm.nih.gov/pubmed/32472168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02793-4
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Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates

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