Inter-subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man.

1. The metabolism of proguanil to the active metabolite cycloguanil has been evaluated in 135 British Troops and 26 Kenyan schoolchildren. 2. Large inter-subject variability was observed in both plasma and urinary concentrations of proguanil and cycloguanil after standard doses of drug. 3. Based on...

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Bibliografiske detaljer
Main Authors: Ward, S A, Watkins, W M, Mberu, E, Saunders, J E, Koech, D K, Gilles, H M, Howells, R E, Breckenridge, A M
Format: Artigo
Sprog:Inglês
Udgivet: 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1379805/
https://ncbi.nlm.nih.gov/pubmed/2757894
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