Inter-subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man.

1. The metabolism of proguanil to the active metabolite cycloguanil has been evaluated in 135 British Troops and 26 Kenyan schoolchildren. 2. Large inter-subject variability was observed in both plasma and urinary concentrations of proguanil and cycloguanil after standard doses of drug. 3. Based on...

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Autors principals: Ward, S A, Watkins, W M, Mberu, E, Saunders, J E, Koech, D K, Gilles, H M, Howells, R E, Breckenridge, A M
Format: Artigo
Idioma:Inglês
Publicat: 1989
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1379805/
https://ncbi.nlm.nih.gov/pubmed/2757894
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