Enantioselective Formation of CF(3)-Bearing All-Carbon Quaternary Stereocenters via C-H Functionalization of Methanol: Iridium Catalyzed Allene Hydrohydroxymethylation

Using an iridium catalyst modified by PhanePhos, CF(3)-allenes react with methanol to form branched products of hydrohydroxymethylation as single regioisomers with excellent levels of enantiomeric enrichment. This hydrogen auto-transfer process enables catalytic enantioselective formation of acyclic...

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Publicado en:J Am Chem Soc
Main Authors: Holmes, Michael, Nguyen, Khoa D., Schwartz, Leyah A., Luong, Tom, Krische, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651675/
https://ncbi.nlm.nih.gov/pubmed/28603973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b04374
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