Cyclometallated Iridium-PhanePhos Complexes Are Active Catalysts in Enantioselective Allene-Fluoral Reductive Coupling and Related Alcohol-Mediated Carbonyl Additions that Form Acyclic Quaternary Carbon Stereocenters

Iridium complexes modified by PhanePhos catalyze the 2-propanol-mediated reductive coupling of diverse 1,1-disubstituted allenes 1a-1u with fluoral hydrate 2a to form CF(3)-substituted secondary alcohols 3a-3u that incorporate acyclic quaternary carbon-containing stereodiads. By exploiting concentra...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Schwartz, Leyah A., Holmes, Michael, Brito, Gilmar A., Gonçalves, Théo P., Richardson, Jeffery, Ruble, J. Craig, Huang, Kuo-Wei, Krische, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423978/
https://ncbi.nlm.nih.gov/pubmed/30681850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b11868
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