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Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand

The 18 kDa translocator protein (TSPO) is found in mitochondrial membranes and mediates the import of cholesterol and porphyrins into mitochondria. In line with the role of TSPO in mitochondrial function, TSPO ligands are used for a variety of diagnostic and therapeutic applications in animals and h...

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Publicat a:Science
Autors principals: Jaremko, Łukasz, Jaremko, Mariusz, Giller, Karin, Becker, Stefan, Zweckstetter, Markus
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650047/
https://ncbi.nlm.nih.gov/pubmed/24653034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1248725
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